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The 5-aminosalicylic acid (5-ASA) treatment blunts the increase in circulating TMAO in mice on the choline-supplemented high-fat diet (Woongjae Yoo et al., 2021)
This was accompanied by decreased regional blood flow in the dorsolateral prefrontal cortex, the brain region responsible for executive functions, indicative of extra energy source availability (129)
Therefore, since little is known about L-carnitine-related benefits limiting acute VPA toxicity, we designed this study in VPA-poisoned patients 1to describe VPA toxicokinetics
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