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The determination of the strength of the recommendation was based on the strength of evidence, but also involved extensive discussion of clinical usefulness, clinical applicability, and adverse events

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Respiratory depression is the chief risk for elderly patients treated with opioids, and has occurred after large initial doses were administered to patients who were not opioid-tolerant or when opioids were co-administered with other agents that depress respiration

In vitro experiments showed that panaxydol inhibited lipopolysaccharide (LPS)-induced ferroptosis and inflammation in bronchial epithelial cells, BEAS-2B cells