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Second, while this study proposes a mechanistic hypothesis based on proteomic findings, future studies using immunohistochemistry and cellular co-localization are needed to identify the cellular sources of CINC-3 and CNTF expression and clarify DPs cellular targets.Thirdly, this study is the absence of behavioral assessments such as von Frey test, weight bearing, or gait analysis, future studies will incorporate these approaches to further investigate the functional implications of the molecular changes observed

Bax protein is considered to play a vital role in cellular death (apoptosis)

The entire process of mitochondrial fusion can be briefly summarized as mitochondrial trans-bolus, mitochondrial outer membrane fusion, and mitochondrial inner membrane fusion (He and Maheshwari, 2023)

Iterative optimization allows us to enhance stability, maximize drug loading, and achieve desired release profiles, while minimizing leakage and degradation