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JS: Conceptualization, Investigation, Writing review & editing

(2004) Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease

The procedure typically takes about 30-60 minutes and is well-tolerated, with most patients experiencing only mild discomfort

Importantly, CYP2E1-overexpressing HepG2 cells were previously validated for the study of APAP hepatotoxicity, with formation of APAP-protein adducts, mitochondrial damage, and cell death occurring similar to primary mouse and human hepatocytes [51], and our preliminary doseresponse and time course data were consistent with those earlier results (Suppl