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A second hydrogen peroxide molecule acts as a reducing agent to regenerate the resting state enzyme, producing a molecule of oxygen and water.36 Hydrogen peroxide though at low amounts tends to regulate some physiological processes such as signaling in cell proliferation, cell death, carbohydrate metabolism, mitochondrial function, and platelet activation and maintenance of normal thiol redox-balance,37 however, at high concentrations it has been reported to be very deleterious to cells.38 Hence, the ability of CAT to effectively limit H2O2 concentration in cells underlines its importance in the aforementioned physiological processes as well as being a first line antioxidant defense enzyme

In vivo studies showed that intraperitoneal injection of DEX 20 g/kg 1 h before surgery alleviated LPS-induced ALI in mice and reversed LPS-induced upregulation of MDA and downregulation of GPX4 in the lung

doi: 10.3389/fimmu.2026.1737751 Received 02 November 2025 Revised 13 December 2025 Accepted 19 January 2026 Published 04 February 2026 Volume 17 - 2026 Edited by Luiz Henrique Agra Cavalcante-Silva, Federal University of Alagoas, Brazil Reviewed by Zhou Yang, Fudan University, China Zhenyu Guo, Fudan University, China Updates Copyright 2026 Xu, Chen, Yuan, Zhang, Wang, Xi, Pan, Li and Lu

The retatrutide reconstitution chart uses the same 10 mg/mL concentration target