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Description
While the etiology of NTD is multifactorial, some studies have found that blood concentrations of homocysteine or holo-transcobalamin to be lower in NTD-affected infants and mothers compared to non-affected controls (reviewed in 59)

In support of this idea, when holoTC concentrations were subtracted from total vitamin B-12 concentrations, the remaining vitamin B-12, represented by the holohaptocorrin (holoHC) fraction of serum vitamin B-12, was unaffected by the concentration of plasma folate (Figure 8B)

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