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81902856, 81872270), the Natural Science Foundation Project of Chongqing (cstc2019jscx-dxwtBX0019), the Science and Technology Research Program of Chongqing Municipal Education Commission (HZ2021006, KJZD-M202000401), Chongqing Medical Scientific Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau), the Innovative and Entrepreneurial Team of Chongqing Talents Plan, the Future Medical Youth Innovation Team of Chongqing Medical University (W0036, W0101), and the Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University