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doi: 10.1016/j.bbrc.2018.08.130 88 OkusaMDRosinDLTraceyKJ
Compared with Actilyse, it has a longer half-life (22 minutes versus 3.5 minutes), about 15 times greater fibrin selectivity and 80 times greater resistance to plasminogen activator inhibitor-1 (PAI-1), an inhibitor of thrombolysis
Treatment with rapamycin reversed these impairments by downregulating the phosphorylated AKT/mTOR pathway and upregulating BNIP3, AMBRA1, and Parkin expression
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