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The mean fluorescence intensity of CellROX was significantly higher in immune cells from TLS than those from the spleen or peripheral blood (Supplemental Figure 4)

ROS generation is controlled under physiological conditions but increases under pathological conditions, with high ROS levels potentially inducing carcinogenesis and oxidative stress-stimulated diseases

The entry of the virus itself and the viral load can modulate oxidative stress and the inflammatory response, both processes that directly contribute to COVID-19 severity (Fig