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The endpoint of B-cell receptor stimulation is the activation of the NF-B and MAP kinase pathways, which results in the proliferation, migration, and survival of CLL cells
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Schaeffer AJ, Datta NS, Fowler JE Jr, Krieger JN, Litwin MS, Nadler RB, Nickel JC, Pontari MA, Shoskes DA, Zeitlin SI, et al
By binding intestinal BAs and promoting their excretion, BASs reduce the BA pool returning to the liver, potentially decreasing BA-induced hepatotoxicity and altering systemic BA signals (134)
