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Somewhat contradictory to the observations in animals, Savage et al (56) reported 27 prepubertal children with severe GH insensitivity syndrome (GHIS or Severe Primary IGF Deficiency (SPIGFD)) to have a median (range) birth weight SDS of -0.72 (1.75 - (-3.29)) and birth length SDS of -1.59 (0.63 - (-3.63))

Vitamin B2 (Riboflavin) Riboflavin is naturally present in some foods and is an essential component of two major coenzymes that play major roles in energy production, cellular function, metabolism of fats and growth and development

Studies have reported that PGC-1 not only regulates mitochondrial biogenesis, mitochondrial transcription and replication, and antioxidant systems but also participates in regulating mitochondrial fission and fusion and maintaining mitochondrial homeostasis (Zarch et al., 2009)