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The conserved cysteine residue at position 36 in GpoA corresponds to the selenocysteine (Sec) residue at position 46 in human GPX4 (Fig
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In turn, Per and Cry dimerize, acting as the negative limb of the feedback loop to inhibit Clock:Bmal1 transcriptional activity for the cycle to repeat, and degradation of Per and Cry proteins are responsible for terminating repression and restarting transcription
