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PEPITEM-derived tripeptides reduced splenomegaly, the enlargement of the spleen that indicates systemic inflammation, and limited the expansion of CD4+, CD8+, TH1, and TH17 cell populations
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HIF-1 serves as the molecular linchpin, simultaneously upregulating VEGF while activating PI3K/Akt/mTOR and MAPK signaling cascades, thereby creating a feedforward loop that sustains tumor vascularization and progression (Figure 4) (Mabeta and Steenkamp, 2022
Suzuki, M
