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In contrast, anti-inflammatory approaches have produced the most consistent outcomes, including reductions in pro-inflammatory cytokines (IL-1 and TNF-), elevations in anti-inflammatory mediators (IL-10 and LXA4), and structural restoration within the hippocampus and cerebellum, particularly increased neuronal density and Purkinje cell number

of 0.9 (PDB code 2x8c) 19