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(54) PATHOPHYSIOLOGY OF ALCOHOL AND CIRRHOSIS Acetaldehyde is a metabolite of alcohol that, when it accumulates, produces liver damage as the result of its ability to generate formation of DNA adducts such as sites without purine or pyrimidine (Figure 3)

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Oxidative stress When the organism suffers from harmful stimulation, it will produce excessive ROS, which causes the imbalance of between the oxidation system and the antioxidant system and induce oxidative stress (Su et al., 2023)