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Studies focusing on c-MET inhibition has reported EGFR sensitivity towards erlotinib drug as well as erlotinib sensitization in a dominant-active c-Src subset of EGFR overexpressing HNSCC lines [94]

Indeed, it has been established that overactivation of the NAD + -dependent PARP can trigger cell death due to NAD + depletion [69, 107, 108]

doi: 10.3389/fimmu.2025.1543096 Received 10 December 2024 Accepted 21 March 2025 Published 22 April 2025 Volume 16 - 2025 Edited by Prakash Radhakrishnan, University of Nebraska Medical Center, United States Reviewed by Mara P

Conclusion In conclusion, the proved benefits of ginger are many and significant, and the lack of knowledge about the biological mechanisms that underlie these effects should not deter one from making an informed and wise use of this useful spice