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Typically, the mixed solution should be used within 30 days

Compared with individuals with higher vitamin B12 concentrations, those with lower vitamin B12 concentrations were more likely to be obese

Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

Some maintenance treatments (like certain oral targeted agents, or prophylactic antimicrobials in survivors) are twice daily