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Even TfR, the most widely and successfully investigated target for receptor-mediated brain drug delivery, is present throughout the body [8, 19, 20]

Results from studies enrolling patients with previous bariatric surgery are in line with those including surgically nave individuals 64,69,72

Addressing the mechanism of the H 2 O 2 -induced macrophage death, immunoblotting for cleaved caspase-3, measurement of released IL-1 and IL-18, and use of nercostatin-1 did not support caspase-3-dependent apoptosis, inflammasome activation or necroptosis as the underlying cause of the cytotoxicity, respectively