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Immunological testing G01N33/68Chemical analysis of biological material, e.g

PT2385 is one of the very few HIF-2 inhibitors investigated in preclinical models of GBM and works by preventing allosteric heterodimerization with HIF-1 when it binds to HIF-2 PAS-B domain (156)

They also sensitize the mPTP to calcium-dependent opening, triggering loss of mitochondrial integrity and bioenergetic collapse (57)