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CSI Transact on ICT 11:11
The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase

In addition, DORs are found in peripheral tissues, including immune cells, and may play a key role in modulating inflammatory responses [50,52,53]

Although the ability to produce ATP is limited, aerobic glycolysis can provide tumor cells with rapid access to ATP and biosynthetic intermediates for proliferation [30]
