![isotopically labeled glutathione glutamate Hyperpolarized [5-13C,4,4-2H2,5-15N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine Catabolism of extracellular glutathione supplies](https://www.pnas.org/cms/10.1073/pnas.2120595119/asset/05dc09bc-81dd-4a6b-9564-2534eee7ab4f/assets/images/large/pnas.2120595119fig01.jpg)
isotopically labeled glutathione glutamate Hyperpolarized [5-13C,4,4-2H2,5-15N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine Catabolism of extracellular glutathione supplies
Description
The nonenzymatic initial reaction between 1 M roGFP2 WT (S 2 ) and physiological millimolar GSH concentrations was too slow to be detectable and to be of any relevance in the presence of glutaredoxins in accordance with previous analyses 32
![isotopically labeled glutathione glutamate Hyperpolarized [5-13C,4,4-2H2,5-15N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine Catabolism of extracellular glutathione supplies](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10268-2/MediaObjects/41586_2026_10268_Fig1_HTML.png)
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![isotopically labeled glutathione glutamate Hyperpolarized [5-13C,4,4-2H2,5-15N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine Catabolism of extracellular glutathione supplies](https://jn.nutrition.org/cms/10.1093/jn/130.4.892S/asset/6db95284-8295-439c-9a4b-945ed2eafa4a/main.assets/gr4_lrg.jpg)
H.O'DonoghueG
![isotopically labeled glutathione glutamate Hyperpolarized [5-13C,4,4-2H2,5-15N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine Catabolism of extracellular glutathione supplies](https://resource.bocsci.com/structure/glutathione-(1s,-2s)-isomer.gif)
Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death
![isotopically labeled glutathione glutamate Hyperpolarized [5-13C,4,4-2H2,5-15N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine Catabolism of extracellular glutathione supplies](https://ars.els-cdn.com/content/image/1-s2.0-S0731708518308628-fx1.jpg)
