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However, in contrast to these findings, one mouse model actually found a 50% increase in M2-like macrophages with implementation of the KD, theoretically creating an immunosuppressive effect that could attenuate therapeutic benefit (112)

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These findings highlight the mucoadhesive nature of chitosan as a key factor in prolonging the residence time of nanoparticles at the absorption site, thereby facilitating improved drug permeation and absorption