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In the former case, attention is focused on the first key enzyme of GSH synthesis, GLCL, and in the latter case on GSTs
The combined administration of PQ with maneb or its closely related chemical, mancozeb, has also been applied to study the effects of PQ on the nigrostriatal dopamine system and was found to reproduce PD symptoms better than PQ alone (Thiruchelvam et al., 2000a,b)

By doing so, we aim to provide a transformative framework for understanding COPD pathogenesis and inform the development of novel, targeted interventions

doi: 10.1542/peds.2011-1580
