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Therefore, arginine deprivation is becoming a novel and promising clinical strategy for metabolism-based cancer therapy (Qiu et al., 2015

3.1 In vitro models: from conventional to 3D spheroid and organoid models Like in other human tumors, traditional cultures of cell monolayer remain widely used in research, providing a controlled environment for rapid drug screening and genetic manipulation

To view a copy of this licence, visit About this article Cite this article Wan, Y., Li, G., Cui, G
