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(2012) 7:e49191

Eighty-five percent of levothyroxine (T4) metabolized daily is deiodinated

Now that we understand how exactly TMA is produced in the gut and that the enzyme can be inhibited, there are grounds for further research into future discovery of drugs targeting the TMA-producing enzyme in the human gut

Current interventions for atherosclerosis that target these risk factors, such as first-line statins (which inhibit 3-hydroxy-3-methyl-glutaryl-CoA reductase and prevent it from decreasing the production of cholesterol) are beneficial in disease prevention and treatment
