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Here we describe the in vitro and in vivo reconstitution of the entire pathway, starting from the as yet uncharacterized gene products of the carnitine degradation gene operon

Given that acetyl-l-carnitine has a neuroprotective action shown in an animal model of ALS [85], it was hypothesised that treatment with acetyl-l-carnitine could help patients with ALS

Kraiss, LW