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These findings may have general implications in the use of total (free + conjugated) oxidative metabolite excretion for determining primary routes of drug clearance and may question the utility of diclofenac as a probe for phenotyping human CYP2C9 activity in vivo via measurement of its pharmacokinetics and total 4'-hydroxy diclofenac urinary excretion

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Figure 1 Genetic Findings in Bipolar Disorder A strong genetic basis for bipolar disorder has been apparent since researchers conducted the first familial and identical twin studies many years ago

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