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In mice, 3-AR receptors mediate cold-induced thermogenesis (223) and pharmacological activation of 3-ARs acutely stimulate lipolysis leading to two-fold increase in energy expenditure, a dramatic ten-fold increase in insulin levels, and 4050% reduction in food intake (98)

Ongoing oxidative stress is linked to many chronic diseases (1) including cancer, cardiovascular disease, diabetes, osteoarthritis, and dementia

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