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Furthermore, Fc-epsilon receptor I (FcRI) activation caused a zinc flux in mast cells [96]
Its primary metabolic effects result from the activation of SIRT1 and AMPK (20), which in turn enhance mitochondrial biogenesis, improve insulin sensitivity through LKB1 activation (21, 22), and decrease de novo lipogenesis by ACC phosphorylation and SREBP-1c/ChREBP downregulation (23)
[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Oconitrillo M, Wickramasinghe J, Omale S, Beitz D, Appuhamy R
Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha
