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MG is detoxified by the glyoxalase route by the sequential actions of GLYI and GLYII in a glutathione (GSH)-dependent manner, while GLYIII facilitates glutathione-independent detoxification under prolonged stress conditions

Insufficiently suppressed hepcidin given the degree of iron deficiency in PV patients strongly suggests that disordered iron metabolism is an important component of the pathobiology of PV

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