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Description
Molecular dynamics simulations Simulations were performed using Gromacs 49,50 (version 2020.4) and the Martini 2.2 P coarse-grained force field 51

On the one hand, sarcopenia is significantly associated with an increased risk of MASLD (106), and in patients with MASLD, sarcopenia is associated with an increased risk of liver fibrosis, independent of obesity or insulin resistance (107)

combined in the same session, they significantly increase the risk of irritation and barrier disruption

In fact, DAMPs and PAMPs engage Toll-like receptors (TLRs) or Nucleotide-Binding Oligomerization Domain-Containing 2 (NOD2), activating NF-B transcriptional regulation, which enhances the levels of the NLRP3 inflammasome in cells
