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Psoriasis patients were found to have increased amounts of LL-37 in their skin lesions, and it appears to promote inflammation by activating plasmacytoid dendritic cells and inducing an autoimmune response-like process
In the Phase 3 REDEFINE 1 trial, the most commonly reported adverse events included nausea, vomiting, diarrhoea, and constipation

Many practitioners recommend 12-16 week cycles with periodic reassessment of goals and response

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