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In practice, this involves: Initial restriction phase (4-6 weeks) Systematic reintroduction of FODMAP categories Personalized maintenance diet based on individual triggers Research indicates the Mediterranean diet may offer superior efficacy for IBS symptom severity, abdominal distention, and quality of life, followed closely by the low-FODMAP diet

This pathway can control the expression of PEBP1, ERK1/2, GPX4, FTH1, ACSL4, and COX2, thereby enhancing the function of hippocampal astrocytes and microglial cells in CUMS model mice (Jiao et al., 2021)