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Conversely, in vitro methods can reliably define the properties of mAbs or of vaccine-induced antibodiesincluding their epitope specificity, binding affinity and avidity, and maturation as well as any potential to enhance fusion, together with their capacities for neutralization and antiviral Fc-dependent effector functions (Fig

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Stromal cells play an important role in tumor heterogeneity and promote tumor cell plasticity via metabolic and epigenetic signals