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This is why, lets say, Ozempic, as just an example Ozempic, its a peptide

Enteric Glia Enteric glia represent a large, structurally and molecularly diverse population of nonneuronal cells that are distributed in all layers and along the length of the GI tract, in close association with the ENS and nerve fibers that innervate the gut (84, 242, 267, 268)
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