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1953 James Watson and Francis Crick publish the double-helix model of DNA, revolutionizing our understanding of genetics and laying the foundation for modern molecular biology

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Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)

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