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A vitamin B12 deficiency can lead to fatigue and other health-related issues

Supplement Vitamin B12 For those with permanent B12 malabsorption, such as individuals with MTHFR gene mutations, vegans/vegetarians, IBD or ileum resection, Vitamin B12 supplementation is generally recommended

Folate is trapped as methyltetrahydrofolate and therefore cannot serve as a substrate for thymidine synthesis

For patients diagnosed with a vitamin B12 deficiencyespecially when caused by problems with absorption in the digestive tract (such as pernicious anemia, certain gastrointestinal conditions, or after specific surgeries)oral supplements may not be effective