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As their name suggests, integral proteins (some specialized types are called integrins) integrate completely into the membrane structure, and their hydrophobic membrane-spanning regions interact with the hydrophobic region of the phospholipid bilayer (Figure 21)

A well-designed skill sound can signal danger, enhance impact, or even invoke safety

The pilocarpine-status epilepticus model in rats resembles the pathophysiology and chronic spontaneous seizures of TLE, whereas the pentylenetetrazole kindling paradigm demonstrates chronic caused limbic seizures