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In Vitro Effects of Artemisia sieberi on Echinococcus granulosus Protoscolices
doi: 10.1038/s41467-023-43315-x 185 FerreiraAVDomiguz-AndrsJNeteaMG
New England Journal of Medicine , 379 (22), 21402150
FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis
