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10.1002/dneu.20635 68 LustigB.JerchowB.SachsM.WeilerS.PietschT.KarstenU.et al
Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study
In the inhibitory pathway, the protease cleaves a region of the serpin, generating an irreversible covalent protease-serpin complex
In addition, ROS can cause overactivation of phosphatidylinositol 3-kinase (PI3K) eAkt by suppressing the activity of the upstream negative regulator phosphatase and tensin homolog (PTEN) in tumor cells [14]
