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Liu Y, Wang X, Zhu Y, Cao Y, Wang L, Li F, et al

Targeted delivery systems, such as encapsulated vitamin C or controlled-release formulations, could minimize gastrointestinal side effects associated with high-dose supplementation

Consequently, inflammatory processes may affect SELENOP production by the liver thus influencing brain Se uptake

Additionally, this study revealed an immunosuppressive TME in brain metastases characterized by reduced CD8 + Tcell infiltration, increased numbers of Treg cells, and reprogrammed myeloid cell populations [277]
