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12 Cross-talk also exists between tryptophan metabolism and bile acid metabolism: tryptophan can modulate gut microbiotabile acid crosstalk by altering BSH-enriched microbes and intestinal FXR signaling, thereby influencing hepatic bile acid synthesis

Yu L, Hammer RE, Li-Hawkins J, et al
For this analysis, highly connected hub metabolites such as Phosphate, AMP, ADP, and ATP molecules were removed due to their connection with hundreds of genes
Conclusion and Perspective Reactive oxygen species is not only a by-product of cellular metabolic programs but also a key signaling molecule involved in directing T cell activation and differentiation