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Following subcutaneous injection, the peptide enters systemic circulation with bioavailability of 14-19% in rats, while intramuscular administration achieves 45-51% bioavailability in beagle dogs, indicating both route-dependent and species-dependent absorption characteristics

Funding The research work was financed solely by the corresponding author

Larger effects in studies enrolling older samples ( 60 years) were observed, but the remaining between-study findings warrant prospective confirmation

If left untreated, cartilage damage will worsen with time and lead to early onset of osteoarthritis (usually within 5-6 years after cartilage injury) Stages of Cartilage Damage Stages I and II of cartilage damage are early stages