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Proactive dose reduction of these concurrent agents is often necessary before tirzepatide escalation

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It is an effector enzyme of G protein-coupled receptors, GPCRs, with seven transmembrane hydrophobic regions, and molecules such as bradykinin, histamine, angiotensin II, M1 muscarinic-like receptors and 1 adrenergic receptors activate PLC- via Gq of the pertussis toxin (PTX)-sensitive Gq subfamily, while M2 and M4 muscarinic-like receptors activate PLC- via G of the PTX-sensitive Go/Gi subfamily ( 2+ , while DAG activates protein kinase C (PKC) together with Ca 2+ ( Figure 1 ) ( Figure 1 PLC- is not only distributed on the cytoplasmic membrane, but also in the nucleus and cytoplasm