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32 JAK-STAT signaling pathway The JAK-STAT signaling pathway is fundamental to immune regulation and plays key roles in infection defense, immune tolerance, and tumor surveillance

J Neurochem 54, 415423.CrossRefGoogle ScholarPubMed Edlund, C, Sderberg, M, Kristensson, K, Dallner, G (1992) Ubiquinone, dolichol, and cholesterol metabolism in aging and Alzheimers disease

Another deleterious mechanism associated with mitochondrial dysfunction is the limitation in ATP production that can cause an energy crisis in neurons (Nicholls, 2013) and calpain-activation are linked to AD (Saito et al., Not only are mitochondria associated with UPS function in regards to ATP production and the generation of ROS, the UPS is also linked to mitochondrial function, as recent studies revealed that the UPS degrades mitochondrial proteins and thus contributes to mitochondrial quality control (Taylor and Rutter, 2011)