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In the motor cortex of ALS patients, glutathione (GSH) levels were reported to be reduced when compared to healthy controls 57

Since the clinical utility of EA was limited both by its diuretic properties, and its lack of isozyme specificity, efforts were made to develop inhibitors with more optimal isozyme specificity and clinical application

Experiments have shown that overexpression of BECN1 significantly increases levels of malondialdehyde (MDA), Fe 2+ , and ROS in cells, promoting the occurrence of ferroptosis induced by CaOx crystals

To become useful again, the body must use a specific enzyme called glutathione reductase to "recycle" it back into the reduced state