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However, oxidative stress-mediated changes in cellular machinery allow Nrf2 to escape the degradation pathways and translocate to the nucleus

The anticonvulsant drugs phenobarbital, phenytoin (Dilantin), and carbamazepine (Tegretol) may also lower plasma vitamin E concentrations in individuals with epilepsy (129)

The combined intervention yielded statistically significant improvements in pain alleviation, functional capacity, serum vitamin D levels, and quality of life as compared to either intervention administered in isolation

For instance, inhibition of apolipoprotein C1 (APOC1) or SLC7A11 promotes ferroptosis in TAMs, which is characterized by increased iron content, downregulated anti-ferroptosis mediators (GPX4, NRF2, SLC7A11, and GSH), and significant ferroptosis-associated mitochondrial changes