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Of late, multiple transcription factors such as TFAP2C, p53, AP-1, STAT, Nrf2, HIF-1, and C/EBP have been linked with the transcriptional regulation of seleno-GPxs [8, 21,22,23,24]
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Proteins were digested into peptides using a high-throughput automated version of the protein aggregation capture workflow 52 on the KingFisher Flex Purification System (Thermo Fisher Scientific)

However, the mechanisms underlying this relationship remain unclear, and further studies are needed
