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Description
Activated microglia secrete chemokines and cytokines that contribute to a hyperactive state of neurons and central sensitization [56,58,60,61]
The cAC10-L4-MMAF in which cAC10 (anti-CD30) linked to the antimitotic auristatin derivative MMAF via a non-cleavable maleimidocaproyl linker was approximately as potent as cAC10-L1-MMAF with a dipeptide linker in vitro against a large panel of cell lines and was equally potent in vivo (Figure 5) [48,49]
High GGT and low ChaC1 expression in cancer cells are pivotal factors in developing drug-resistant phenotypes in tumors (86)
doi: 10.1093/femspd/ftw081
