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It may be mixed with a substance known as a buffering agent or excipient to maintain its stability, purity, and the correct pH for storage and administration
However, a diagnosis of folate deficiency should be considered in such patients when significant elevation in mean cell volume or hypersegmented polymorphonuclear leucocytes are found, especially in subjects with malnutrition, history of alcohol abuse, or in patients hyporesponsive to rHuEPO
